NCT05120401

Causal Relationship Between Dry Eye and Accommodative Spasm

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Far Eastern Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 99 Years
• Healthy volunteers: Accepted

Summary

To investigate the causal relationship of Sicca dry eye patients with presbyopic refractive error and accommodative spasm.

Detailed description

Dry eye is a disease of the ocular surface. Severe dry eye produce symptom of discomfort in and around the eye that drastically affect life quality of the patient. OSDI index is retrieve from a questionnaire specific for these dry eye symptoms, it is an internationally accepted level to reveal the severity of Dry eye disease. One part of the symptom is pain and soreness around the eye. Hyperalgesia is an increase response to a stressful/ noxious stimulus whereas allodynia is a painful response to a normally innocuous stimulus. Our hypothesis state that Sicca Dry eye upregulated inflammatory cytokine in the eye has pre-sensitized the nociceptor nerve fiber in the cornea and orbit, therefore the normally innocuous effort of accommodation and ciliary muscle contraction produce intolerable retro-orbital eye pain, which drives the patient to seek medical attention, on presentations these patient show an elevated OSDI and Pain Index (PI).

Conditions

• Dry Eye

Interventions

Type	Name	Description
DEVICE	presbyopia glasses	fogging for glasses for far and intermediate

Timeline

• Start date: 2021-11-05
• Primary completion: 2024-07-20
• Completion: 2025-10-15
• First posted: 2021-11-15
• Last updated: 2021-11-15

Locations

1 site across 1 country: Taiwan