NCT05103969

Cohort of Tumors With POLE/D1 Mutation

Multicenter Prospective Cohort of Tumors With Pole/D1 Mutation

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Federation Francophone de Cancerologie Digestive · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Primary objective of this study is to identify and describe the clinico-biological and molecular characteristics of tumors with somatic POLE (Polymerase ɛ)/POLD1 mutation identified by molecular biology platforms for all stages and primary sites combined

Detailed description

The identification of patients to be included will be done directly from the tumor genotyping platforms. Indeed, they will be the direct source of the identification of all POLE (Polymerase ɛ) mutations. The platforms will inform the project coordination unit of new cases of mutated cancers as well as the referent investigator, jointly they will be in charge of data entry. The diagnostic and follow-up data of each patient will be collected prospectively.

Conditions

• Tumors
• POLE Exonuclease Domain Mutation
• POLD1 Gene Mutation

Timeline

• Start date: 2021-10-05
• Primary completion: 2025-10-06
• Completion: 2025-10-06
• First posted: 2021-11-02
• Last updated: 2024-07-08

Locations

1 site across 1 country: France