NCT05098340

Circulating circRNA in Acute Ischemic Stroke

Clinical Significance of Circulating circRNA in Acute Ischemic Stroke (CRAST)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: The Affiliated Hospital of Xuzhou Medical University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

CRAST is to analyze the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke.

Detailed description

Circular RNAs have been highlighted to be involved in the pathological process of ischemic stroke (IS). The purpose of this protocol will investigate the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke. Distinctive expression patterns of circRNA will be identified by individual quantitative real time polymerase chain reaction (qRT-PCR). A diagnostic or predictive model will be established using logistic regression. The panel of these altered circRNAs may be associated with acute IS and could serve as a novel diagnostic or predictive method.

Conditions

• Acute Ischemic Stroke

Interventions

Type	Name	Description
GENETIC	Quantitative Real-time polymerase chain reaction	Quantitative Real-time polymerase chain reaction of circular RNA (circRNA).

Timeline

• Start date: 2020-10-01
• Primary completion: 2024-10-30
• Completion: 2024-10-30
• First posted: 2021-10-28
• Last updated: 2024-08-06

Locations

1 site across 1 country: China