Trials / Recruiting
RecruitingNCT05097274
The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation.
An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation (GENPET)
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (estimated)
- Sponsor
- Institute of Cancer Research, United Kingdom · Academic / Other
- Sex
- Male
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The aim of the study is to determine if PET-CT imaging (using contrast recommended in clinical guidelines) is superior to combined bone scan and MRI/CT of the abdomen \& pelvis in detecting the increased incidence of metastasis (nodal/distant outside the pelvis) in men with prostatic carcinoma with mutations in any of the following germline DNA repair genes BRCA1, BRCA2, MSH2, MSH6, MLH1, PMS2, CHEK2, PALB2, ATM.
Conditions
- Prostate Cancer
- BRCA Mutation
- Mismatch Repair Gene Mutation
- ATM Gene Mutation
- HOXB13 Germline Mutation
- CHEK2 Gene Mutation
- PALB2 Gene Mutation
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | MRI pelvis or CT imaging under clinical management for Pr Ca | Individuals to undergo a clinical MRI or CT scan of Pelvis and the study reviews the images. |
| OTHER | Whole body bone scan imaging | bone scan of the whole body (under clinical diagnosis). |
| OTHER | PET-CT imaging | Pt will undergo a PET-CT for their clinical treatment and we will review the images of this scan. |
Timeline
- Start date
- 2015-10-15
- Primary completion
- 2027-12-31
- Completion
- 2032-12-31
- First posted
- 2021-10-28
- Last updated
- 2025-12-16
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT05097274. Inclusion in this directory is not an endorsement.