NCT05085704

Brain Metabolism Observed at 7 Tesla

Brain Metabolism Observed at 7 Tesla in Health and Metabolic Disease.

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 16 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla.

Detailed description

The goal is to establish a protocol to 13C-label (from 13C-glucose) several physiological molecules: glucose, lactate, pyruvate and derived compounds. All of these molecules can undergo oxidation in the citric acid cycle. The intent is to study the 13C labeling pattern of these molecules in control and G1D subjects to determine if downstream products (such as 13C bicarbonate or 13C glutamate) due to oxidation in the mitochondria can be detected in brain or in blood by NMR analysis. While inside the instrument, the subjects may also undergo a 7T MR exam to correlate spectroscopy with brain structure.

Conditions

• Glut1 Deficiency Syndrome 1
• Glucose Metabolism Disorders
• Epilepsy
• Glut1 Deficiency Syndrome 1, Autosomal Recessive
• Glucose Transporter Type 1 Deficiency Syndrome
• Glucose Transporter Protein Type 1 Deficiency Syndrome
• Glucose Transport Defect

Interventions

Type	Name	Description
DEVICE	Magnetic resonance imaging	Medical imaging technique used in radiology to form pictures of the anatomy.

Timeline

• Start date: 2022-05-03
• Primary completion: 2026-09-20
• Completion: 2026-09-20
• First posted: 2021-10-20
• Last updated: 2023-10-25

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study