NCT05074277

Skeletal Response to Simulated Night Shift

Skeletal Response to Simulated Night Shift (SPOTLIGHT Study)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This small intervention study will determine if simulated short-term night shift work (NSW) negatively alters bone metabolism. The specific aim of the study is to determine if NSW acutely uncouples bone turnover markers (BTMs), if sympathetic tone is a mechanism for this disruption and if a resumption of a normal sleep/wake pattern reverses BTM uncoupling. Our hypothesis is that NSW will reversibly uncouple BTMs via increased sympathetic nervous system (SNS) tone.

Conditions

• Osteoporosis
• Circadian Rhythm Sleep Disorder, Shift Work Type

Interventions

Type	Name	Description
BEHAVIORAL	Simulated short term night shift work schedule	Participant sleep schedules (in the experimental arm) will be modified to simulate short-term (3 consecutive nights) night shift work schedule (kept awake at night and offered sleep opportunities during the day instead) in each of two inpatient stays.

Timeline

• Start date: 2022-02-08
• Primary completion: 2025-12-18
• Completion: 2025-12-18
• First posted: 2021-10-12
• Last updated: 2025-12-22

Locations

1 site across 1 country: United States