NCT05070819

Atrial Natriuretic Peptide in Assessing Fluid Status

Role of Atrial Natriuretic Peptide in Assessing of Fluid Status in Cardiac Surgery Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Petrovsky National Research Centre of Surgery · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Biomarkers can play a significant role in fluid status assessment intraoperatively.

Detailed description

Routinely intraoperatively the fluid status assessment is based on central venous pressure and other parameters. Nevertheless, the minority of anesthesiologists use continous dynamic parameters like pulse pressure variation, stroke volume variation and other to manage fluid status. There's a fast acting biomarker that can help anesthesiologist to diagnose and manage the volemic status and possibly guide the infusion therapy better. Pro-ANP is a biomarker that reacts on atria strain and can be used in volemic status assessment in cardiac surgery patients.

Conditions

• Fluid Overload
• Fluid Loss
• Volume Overload
• Cardiac Disease
• Cardiac Output, Low
• Cardiac Output, High

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	pro-ANP	pro-ANP samples and fluid status assessment with functional tests (Teboul test) will be used 8 times intraoperatively.

Timeline

• Start date: 2021-09-23
• Primary completion: 2022-03-28
• Completion: 2022-04-07
• First posted: 2021-10-07
• Last updated: 2025-06-08
• Results posted: 2025-06-08

Locations

1 site across 1 country: Russia