NCT05060614

Analyses of Cerebrospinalfluid in Patients With Delirium

MOLECULAR BIOMARKERS IN DELIRIUM AND DEMENTIA

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 700 (estimated)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The current project aims to measure biomarkers in the cerebrospinalfluid (CSF) and serum samples from patients with delirium. We hope to uncover new insights into the pathophysiology of delirium and explore its link to dementia.

Detailed description

Delirium is a common and serious complication to acute illness, and is characterized by acute disturbances in attention, awareness, and cognition. Dementia is a major risk factor of delirium, and delirium increases the risk of dementia progression and development. As the conditions share both clinical and epidemiological features, some researchers suggest that also pathophysiological links are shared. Understanding delirium pathophysiology, which is poorly understood, may thus help elucidate early molecular mechanisms in dementia. This study aims to to increase our understanding of the pathophysiology of delirium and molecular links between delirium and dementia, by exploring cerebrospinal fluid (CSF) biomarkers.

Conditions

• Delirium

Interventions

Type	Name	Description
PROCEDURE	Hip fracture surgery	Hip fracture surgery

Timeline

• Start date: 2016-09-01
• Primary completion: 2027-12-30
• Completion: 2027-12-30
• First posted: 2021-09-29
• Last updated: 2024-03-12

Locations

1 site across 1 country: Norway