NCT05055895

Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:

Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia: A Retrospective Cohort Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 450 (estimated)
• Sponsor: Gulhane Training and Research Hospital · Other Government
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects. However, limited data are available concerning their contribution to time of onset of delirium. This study aimed to determine the potential association of higher anticholinergic burden to early-onset of delirium superimposed dementia in the older adult.

Conditions

• Delirium
• Anticholinergic Adverse Reaction
• Alzheimer Disease

Interventions

Type	Name	Description
DRUG	Anticholinergic burden	The anticholinergic burden (ACB) was assessed using the Anticholinergic Burden Scale. Higher ACB was described as equal or higher than 1.

Timeline

• Start date: 2005-01-01
• Primary completion: 2021-06-01
• Completion: 2022-12-01
• First posted: 2021-09-24
• Last updated: 2021-09-24

Locations

1 site across 1 country: Turkey (Türkiye)