NCT05053074

Nasal High Flow (NHF) in COPD - Effects on Ventilation in Wakefulness

Nasal High Flow (NHF) Bei COPD - Effekte Auf Die Ventilation im Wachzustand

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Institut für Pneumologie Hagen Ambrock eV · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Controlled randomized crossover trial in patients with chronic obstructive respiratory disease (COPD), who are treated with Nasal High Flow (NHF) therapy during wakefulness with a small amount of CO2 added to the inhaled air to keep the patients' PaCO2 stable despite the washout effect. Aim of the study is to examine respiratory rate, tidal volume and work of breathing under NHF without the CO2 washout effect.

Detailed description

In this controlled randomized crossover trial, 10 stable patients with chronic obstructive respiratory disease (COPD) are treated with Nasal High Flow (NHF) therapy during wakefulness. NHF treatment will inevitably result in increased upper airway washout and thus in a slight reduction of PaCO2 of approximately 2 mmHg. For compensation, a small amount of CO2 is added to the inhaled air during this experimental situation, which keeps the patients' PaCO2 stable. This will allow to examine the effects of NHF therapy on respiratory rate, tidal volume and work of breathing, that are not attributable to the CO2 washout effect.

Conditions

• COPD

Interventions

Type	Name	Description
DEVICE	Nasal High Flow (NHF)	Patients with chronic respiratory failure are treated for 1 h with NHF therapy and with individual O2 supplementation during wakefulness.

Timeline

• Start date: 2021-02-27
• Primary completion: 2021-11-12
• Completion: 2022-03-01
• First posted: 2021-09-22
• Last updated: 2023-05-22

Locations

1 site across 1 country: Germany