NCT05041296

Cardiac MRI for Detection of Acute and Chronic Cardiac Involvement in Patients With Epilepsy

The Epileptic Heart - Multiparametric Cardiac Magnetic Resonance Imaging for Detection and Quantification of Acute and Chronic Cardiac Involvement in Patients With Epilepsy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: University Hospital, Bonn · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: —

Summary

The aim of the study is to use multiparametric cardiac MRI to identify any abnormalities in myocardial structure and function in patients with epilepsy. A two-stage study design is planned as part of the study: 1. In the acute setting, cardiac MRI will be performed in patients before and after a tonic-clonic seizure and compared intraindividually. In this study arm, potential acute seizure-induced myocardial damage will be detected. 2. In the chronic setting, cardiac MRI will be performed in patients with known chronic epilepsy during the seizure-free interval to detect potential chronic myocardial damage (myocardial fibrosis) and compared with a control population. Within the group of epilepsy patients, possible associations with various epilepsy-specific characteristics (e.g., form, cause, onset, duration, and severity of epilepsy) will be investigated.

Conditions

• Epilepsy
• Cardiomyopathies

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cardiac magnetic resonance scan	Multiparametric cardiac magnetic resonance including traditional and quantitative functional and structural parameters

Timeline

• Start date: 2021-03-07
• Primary completion: 2023-12-31
• Completion: 2024-12-31
• First posted: 2021-09-13
• Last updated: 2021-09-13

Locations

2 sites across 1 country: Germany