Trials / Completed
CompletedNCT05025722
Pseudoxanthoma Elasticum (PXE) Natural History Biomarkers in PXE Individuals and Their Biological Non-PXE Siblings
An Evaluation of Pseudoxanthoma Elasticum (PXE) Natural History Biomarkers in PXE Individuals and Their Biological Non-PXE Siblings
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 48 (actual)
- Sponsor
- Daiichi Sankyo · Industry
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
This PXE biomarker study aims to characterize the levels of inorganic pyrophosphate (PPi), pyridoxal 5´-phosphate (PLP), and other biomarkers relevant to PXE and ectopic calcification in both PXE patients and their biological siblings who are PXE carriers or normal non-PXE individuals.
Detailed description
This non-interventional PXE study is designed to assess differences in circulation levels of selective biomarkers related to PXE and tissue-nonspecific alkaline phosphatase (TNAP) inhibition, between PXE patients, PXE carriers, and non-PXE normal individuals.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Non Interventional | This is an observational study. |
Timeline
- Start date
- 2021-08-30
- Primary completion
- 2022-08-11
- Completion
- 2022-08-11
- First posted
- 2021-08-27
- Last updated
- 2022-09-06
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT05025722. Inclusion in this directory is not an endorsement.