NCT05024799

Effect of Different Sedation and Analgesia Strategies on Patients With Mechanical Ventilation

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: The Affiliated Hospital of Qingdao University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Most patients in ICU are treated with a combination of analgesics and sedatives in most cases. Due to the different mechanism of different sedative and analgesic drugs, different antagonistic or synergistic effects may occur when combined with drugs, resulting in different clinical effects, especially significant effects on ventilators for patients with assisted breathing. Therefore, this study hopes to compare the effects of different sedative and analgesic drug combinations on the duration of mechanical ventilation for patients with ventilators, so as to guide the clinical adoption of a more reasonable sedative and analgesic scheme.

Conditions

• Respiratory Insufficiency

Interventions

Type	Name	Description
DRUG	Fentanyl, propofol	The patients in this group will be administered with fentanyl and propofol
DRUG	fentanyl and dexmedetomindine	The patients in this group will be administered with fentanyl and dexmedetomindine
DRUG	Butorphanol and propofol	The patients in this group will be administered with butorphanol and propofol
DRUG	Butorphanol and dexmedetomindine	The patients in this group will be administered with butorphanol and dexmedetomindine

Timeline

• Start date: 2022-01-01
• Primary completion: 2024-12-01
• Completion: 2024-12-01
• First posted: 2021-08-27
• Last updated: 2021-08-27