NCT05022043

Serum Presepsin as Early Predictor for Neonatal Early-onset Sepsis

At Admission Serum Presepsin as Early Predictor for Disease Severity and Positive Blood Culture for Neonates With Early-onset Sepsis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 124 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 1 Day – 7 Days
• Healthy volunteers: Not accepted

Summary

124 neonates aged ≤7 days with suspected EOS were clinically evaluated using SNAP-II and gave blood samples for BC, total leucocytic count (TLC), lymphocytic and neutrophil count, and ELISA estimation of serum levels of PSP, procalcitonin (PCT), and tumor necrosis factor-α (TNF-α). Enrolled neonates were categorized as Confirmed EOS: neonates with evident clinical sepsis manifestations and positive BC, Suspected EOS: neonates with evident clinical sepsis manifestations but had negative BC and No EOS included neonates free of evident clinical sepsis manifestations, had negative BC and showed no deterioration till 72-hr after admission.

Conditions

• Neonatal Sepsis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Serum Presepsin	Estimation of Serum Presepsin at time of admission

Timeline

• Start date: 2019-03-01
• Primary completion: 2020-12-30
• Completion: 2021-06-15
• First posted: 2021-08-26
• Last updated: 2021-08-26

Locations

1 site across 1 country: Egypt