NCT05014997

TyG Index Levels in Klinefelter Syndrome

Triglyceride-Glucose Index Levels in Patients With Klinefelter Syndrome and Its Relationship With the Endothelial Dysfunction and Insulin Resistance: A Cross-sectional Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Gulhane School of Medicine · Academic / Other
• Sex: Male
• Age: 18 Years – 28 Years
• Healthy volunteers: Accepted

Summary

It is well known that the frequency of cardiometabolic diseases are increased in patients with Klinefelter Syndrome. The triglyceride-glucose index (TyG index) is a simple surrogate marker of insulin resistance and is also associated with various cardiometabolic diseases. The aim of this study to investigate the TyG index levels and its relationship with insulin resistance and endothelial dysfunction in patients with KS.

Detailed description

From the patient database of our Endocrinology department we randomly included a total of 30 patients with KS and 32 healthy controls in the study. All the recorded data in the database were registered under the approval of Local Ethical Committee of Gulhane School of Medicine. The clinical and laboratory parameters, TyG index, asymmetric dimethylarginine (ADMA), homeostatic model assessment of insulin resistance (HOMA-IR) and high-sensitivity C-reactive protein (hs-CRP) levels were gathered from the database and the triglyceride-glucose index was calculated by the help of pre-measured laboratory parameters.

Conditions

• Cardiac Event
• Klinefelter Syndrome
• Endothelial Dysfunction

Interventions

Type	Name	Description
OTHER	no intervention	this study was designed as retrospective observational study

Timeline

• Start date: 2013-02-10
• Primary completion: 2014-10-01
• Completion: 2017-03-01
• First posted: 2021-08-20
• Last updated: 2021-08-20