NCT05002829

Restricted or Liberal Antibiotics After Appendectomy - Denver Health

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR): A Randomized Controlled Trial at Denver Health

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 657 (actual)
• Sponsor: Denver Health and Hospital Authority · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

Conditions

• Appendicitis

Interventions

Type	Name	Description
OTHER	Restricted Duration of SOC Antibiotic Use	Standard of Care Antibiotic use will be restricted to none or up to 24 hours of post-operative antibiotics.
OTHER	Liberal Duration of SOC Antibiotic Use	Standard of Care Antibiotic use will be permitted for 24 hours or up to 4 days of post-operative antibiotics.

Timeline

• Start date: 2021-11-01
• Primary completion: 2025-07-16
• Completion: 2025-07-16
• First posted: 2021-08-12
• Last updated: 2025-10-31

Locations

1 site across 1 country: United States