Trials / Completed
CompletedNCT04995185
18F-FMISO PET Guided Dose Escalation in Nasopharyngeal Carcinoma - a Feasibility and Planning Study
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 9 (actual)
- Sponsor
- National Cancer Centre, Singapore · Academic / Other
- Sex
- All
- Age
- 21 Years – 99 Years
- Healthy volunteers
- Not accepted
Summary
This study aims to investigate the use of 18F-FMISO PET in identifying hypoxic subvolume for dose escalation radiotherapy in nasopharyngeal cancer and thus improve local control without significant increase in toxicities.
Detailed description
The specific aims of this study are: 1. To establish hypoxia imaging in NPC patients 2. Investigate the dynamics of tumor hypoxia before and during chemoradiation 3. Integrate hypoxia imaging into radiation treatment planning protocols 4. Design hypoxia adapted radiation schedules 5. Identify candidate hypoxia biomarkers
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | (18)F-fluoromisonidazole (FMISO) | Patients do not need to be fasted prior to intravenous injection of 370MBq ± 10% (18)F-fluoromisonidazole. Scanning will be performed two hours after the injection. Patients will be scanned with their thermoplastic shell used in routine radiotherapy treatment for 10 minutes, followed by approximately 5 minutes scan of the upper chest. |
Timeline
- Start date
- 2017-06-20
- Primary completion
- 2020-12-30
- Completion
- 2020-12-30
- First posted
- 2021-08-06
- Last updated
- 2024-05-16
Locations
2 sites across 1 country: Singapore
Source: ClinicalTrials.gov record NCT04995185. Inclusion in this directory is not an endorsement.