NCT04992975

Brain Iron Toxicity and Neurodegeneration - A 7T MRI Study

Brain Iron Toxicity and Neurodegeneration - An Ultrahigh Field (7T) MRI Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Nottingham University Hospitals NHS Trust · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: —

Summary

A longitudinal observational neuroimaging study of individuals with Early Onset Alzheimer's disease during the prodromal phase, and matched control group - Ultrahigh Field MRI study at 7T

Detailed description

This study aims to determine whether high resolution MRI at 7T and Quantitative Susceptibility Mapping (QSM) can demonstrate a specific pattern of iron overload in strategically important areas of brain as a sensitive marker of pathological Alzheimer's disease i.e. patients with subjective or mild cognitive impairment associated with Amyloid or tau pathological state in the cerebrospinal fluid.

Conditions

• Prodromal Alzheimer's Disease
• Mild Cognitive Impairment

Interventions

Type	Name	Description
OTHER	MRI at 7T	MRI at 7T

Timeline

• Start date: 2021-09-10
• Primary completion: 2025-03-01
• Completion: 2025-03-01
• First posted: 2021-08-06
• Last updated: 2024-03-21

Locations

1 site across 1 country: United Kingdom