NCT04987268

CHIP and Residual Cardiovascular Event Tendency After Smoking Cessation

Clonal Hematopoiesis of Indeterminate Potential and Residual Cardiovascular Event Tendency After Smoking Cessation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,029 (actual)
• Sponsor: Shenyang Northern Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

In order to identify the association between clonal hematopoiesis of indeterminate potential (CHIP) and cardiovascular risks after smoking cessation, this study intends to recruit ACS patients undergoing complete revascularization and perform whole-exome sequencing for enrolled patients to identify the prevalence of CHIP mutations. After 1-year follow-up, the relationship of presence of CHIP mutations and the occurrence of MACCEs will be explored, irrespective of smoking cessation or not. CHIP may be a potential risk factor of poor prognosis of ACS.

Conditions

• ACS
• Clonal Hematopoiesis of Indeterminate Potential
• Smoking Cessation

Interventions

Type	Name	Description
GENETIC	clonal hematopoiesis of indeterminate potential	Whole-exome sequencing is performed to detect the presence of clonal hematopoiesis of indeterminate potential (CHIP)

Timeline

• Start date: 2021-08-20
• Primary completion: 2022-08-20
• Completion: 2023-08-20
• First posted: 2021-08-03
• Last updated: 2025-09-10

Locations

1 site across 1 country: China