NCT04986748

Using QPOP to Predict Treatment for Sarcomas and Melanomas

Q-SAM (Using QPOP to Predict Treatment for Sarcomas and Melanomas)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: National Cancer Centre, Singapore · Academic / Other
• Sex: All
• Age: 21 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

This is a multi-cohort proof of concept study involving patients with sarcomas or melanomas. Patient models, both two- and three-dimensional, will be derived from tumour samples. These will then be used to evaluate drug sensitivities ex vivo. Enrolled patients will undergo resections or biopsies as part of standard-of-care, which will be used to generate patient models. Patients will receive standard-of-care systemic treatment. Patient models will also be subjected up to a 14-drug screening panel. The majority of drugs in the respective drug panels has been shown to have activity in the respective cancers and would be used in the standard-of-care setting by treating physicians.

Detailed description

Hypothesis: Ex vivo drug testing on patient-derived models using QPOP can identify drug sensitivities and combinations which may have clinical efficacy against sarcomas and melanomas. Specific aim 1: To derive patient models, both two- and three-dimensional, of sarcomas and melanomas Specific aim 2: To perform ex vivo drug testing on patient models of sarcoma and melanoma using QPOP Specific aim 3: To assess the efficacy of phenotype directed therapy using QPOP to assign treatment after progression on standard-of-care treatment in sarcoma and melanoma

Conditions

• Sarcoma
• Melanoma

Timeline

• Start date: 2020-09-08
• Primary completion: 2028-10-31
• Completion: 2028-12-31
• First posted: 2021-08-03
• Last updated: 2025-07-01

Locations

1 site across 1 country: Singapore