NCT04978077

Networks of Bacterium-Metabolite Interactions in the Small Intestine

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Probands with an Ileo- or Colostomy are assigned to consume a test meal which is either high in fat or high in carbohydrates. After the test meal samples from the stoma, urine, blood and skin are retrieved. These will be subjected to large scale analyses of microbiota and metabolite content. To get a better comparability test subjects will consume a standardized liquid diet three days before the study day.

Detailed description

Between both study days a two week wash out phase will be done. During the study day sampling will be done at set time points until 8 hours after the consumption of the test meal.

Conditions

• Diet, Healthy
• Microbial Colonization

Interventions

Type	Name	Description
OTHER	Test meal (high fat = Nutricia Calogen®, or high carbohydrate = Nutricia preOp®)	After a night fast participants will drink the test meal

Timeline

• Start date: 2021-12-16
• Primary completion: 2024-11-30
• Completion: 2024-11-30
• First posted: 2021-07-27
• Last updated: 2024-12-11

Locations

1 site across 1 country: Switzerland