NCT04976010

Single Cell Leukocyte Landscapes and Cardiovascular Risk in Children With Chronic Kidney Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 38 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: All
• Age: 5 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

Chronic kidney disease (CKD) is associated with an increased cardiovascular mortality. In particular children with early-onset CKD have a lifelong increased risk to suffer from cardiovascular disease (CVD). Therefore, children with CKD deserve our attention. The immune system in children with CKD is disturbed, exhibiting pro-inflammatory features. Therefore, we aim to learn more about the characteristics of the immune system in early-onset CKD. In this project PBMC of pediatric CKD patients and age-matched healthy controls will be analysed and compared using CITE-Seq as a multimodal scRNAseq phenotyping method. All patients will be clinically characterized to integrate cardiovascular and immunological data.

Conditions

• Chronic Kidney Diseases
• Cardiovascular Diseases
• Microbial Colonization
• Aging

Interventions

Type	Name	Description
OTHER	No intervention	There will be no intervention in the separate goups, as this is an observational study

Timeline

• Start date: 2021-07-17
• Primary completion: 2021-11-19
• Completion: 2021-11-19
• First posted: 2021-07-26
• Last updated: 2022-02-08

Locations

1 site across 1 country: Germany