NCT04962412

Predicting Poor Outcomes of Cardiac Surgery-Associated Acute Kidney Injury Using Novel Biomarkers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 3,152 (actual)
• Sponsor: Guowei Tu · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: —

Summary

The aim of this study was to identify and validate novel biomarkers including functional tests for detecting AKI, AKI progression and other poor outcomes.

Detailed description

Cardiac surgery-associated acute kidney injury (CSA-AKI) is the second most common type of AKI after septic AKI and is associated with increased mortality and morbidity. The progression of AKI with multiple organ failure can result in poor outcomes. Several novel biomarkers for earlier detection of AKI, discrimination of etiologies, and prediction of outcomes were developed. However, the availability of these novel biomarkers may be limited by its expense or reimbursement issues in different countries. In present study, we conduct a large cohort to identify and validate novel biomarkers including functional tests for detecting AKI, AKI progression and other poor outcomes.

Conditions

• Acute Kidney Injury
• Critical Illness

Interventions

Type	Name	Description
OTHER	Standard care "bundle"	The management for AKI patients were performed by implementing a standard care "bundle" suggested by the Kidney Disease Improving Global Outcome (KDIGO) guideline.

Timeline

• Start date: 2021-05-12
• Primary completion: 2024-12-31
• Completion: 2025-05-31
• First posted: 2021-07-15
• Last updated: 2025-09-05

Locations

1 site across 1 country: China