NCT04953572

Treatment of Cartilage Defects With Peripheral Blood Stem Cells

Autologous Peripheral Blood Mesenchymal Stem Cell Transplantation for Repair of Degree IV Local Cartilage Injury of Knee Joint

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 252 (estimated)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Knee joint cartilage cells metabolize slowly, and it is difficult to repair themselves after injury. Any knee joint trauma or the progression of osteoarthritis may lead to the progression of cartilage or osteochondral defects. Compared with bone marrow mesenchymal stem cells (MSCs), peripheral blood MSCs have better chondrogenic differentiation ability. At the same time, the mobilization of peripheral blood MSCs and the advancement of extraction technology also make it feasible to treat osteochondral damage by using peripheral blood MSCs. The purpose of this study is to evaluate the therapeutic effect of surgical transplantation of autologous peripheral blood MSCs to repair knee joint Ⅳ-degree localized cartilage injury, and to explore a new treatment for osteochondral defects based on the foundation of the research group's previous research.

Detailed description

1. Explore the clinical efficacy of autologous peripheral blood mesenchymal stem cell transplantation in the treatment of osteochondral defects 2. Exploring the characteristics of cartilage regeneration in autologous peripheral blood mesenchymal stem cell transplantation

Conditions

• Cartilage Injury

Interventions

Type	Name	Description
GENETIC	autologous peripheral blood mesenchymal stem cell	Transplantation of autologous peripheral blood mesenchymal stem cell
PROCEDURE	Microfracture	Microfracture
COMBINATION_PRODUCT	Microfracture + collagen membrane	Microfracture plus collagen membrane transplantation
PROCEDURE	Autologous osteochondral transplantation	Autologous osteochondral transplantation

Timeline

• Start date: 2021-08-01
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2021-07-08
• Last updated: 2021-07-08

Locations

1 site across 1 country: China