NCT04946682

Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 484 (estimated)
• Sponsor: Wen-hong Zhang · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Encephalitis and meningitis are serious central nervous system diseases. There is currently a lack of comprehensive and accurate diagnosis and treatment pathways. Therefore, we conducted this multicenter, prospective, and randomized controlled study. It was designed to evaluate the diagnostic performance and its impact on the outcomes of the patients enrolled. As such, we came to the results of the optimal process of diagnosis and treatment strategy of encephalitis/meningeal syndromes with improved effective treatments.

Conditions

• Encephalitis
• Meningitis
• Meningoencephalitis
• Next-Generation Sequencing
• Polymerase Chain Reaction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Types of etiological diagnostic methods	In Group of mNGS, all patients will be tested by meta next generation sequncing on admission, while patients in Group of PCR will be tested by polymerase chain reaction in accordance with the method in the guidelines.

Timeline

• Start date: 2021-04-14
• Primary completion: 2022-04-14
• Completion: 2023-04-30
• First posted: 2021-07-01
• Last updated: 2021-07-01

Locations

7 sites across 1 country: China