NCT04924985

Goal-directed CPR Using Cerebral Oximetry

Goal-Directed Cardiopulmonary Resuscitation in Cardiac Arrest Using a Novel Physiological Target

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The proposed study is a single-center, randomized controlled pilot trial of adults who suffer in-hospital cardiac arrests. Using cerebral oxygenation and end-tidal carbon dioxide physiological targets to predict survival and neurological outcome, the impact of physiological-feedback CPR will be assessed. 150 adult patients who have a cardiac arrest event at NYU Tisch Hospital will be randomized to one of two treatment groups: (1) Physiological-Feedback CPR or (2) Non-Physiological (Audiovisual) Feedback CPR.

Conditions

• Ischemia
• Reperfusion Injury

Interventions

Type	Name	Description
OTHER	Non-Physiological Feedback CPR	Non-physiologically guided CPR using AV feedback (integrated into defibrillators)
OTHER	Physiological Feedback CPR	Physiological feedback CPR using an optimal regional O2 Saturation (rSO2), End-tidal CO2 (ETCO2) or combined (rSO2/ETCO2) target

Timeline

• Start date: 2022-02-11
• Primary completion: 2025-07-31
• Completion: 2025-07-31
• First posted: 2021-06-14
• Last updated: 2025-03-27

Locations

1 site across 1 country: United States