NCT04916197

Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET)

Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With Endovascular Thrombectomy on Long-term Prognosis in Patients With Acute Ischemic Stroke (PPDET)

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 368 (estimated)
• Sponsor: Beijing Chao Yang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Dexmedetomidine can attenuate the activity of the sympathetic nervous system under stress response and improve ischemia-reperfusion injury. The investigators hypothesized that the prolonged sedation of dexmedetomidine after successful reperfusion of endovascular thrombectomy may improve the clinical outcome of acute ischemic stroke patients.

Detailed description

Endovascular treatment with mechanical thrombectomy is the standard treatment for acute large vessel occlusion. Dexmedetomidine is a commonly used sedative in endovascular thrombectomy of acute ischemic stroke. Dexmedetomidine can attenuate the activity of the sympathetic nervous system under stress response and improve ischemia-reperfusion injury. The investigators hypothesized that the prolonged sedation of dexmedetomidine after successful reperfusion of endovascular thrombectomy may improve the clinical outcome of acute ischemic stroke patients.

Conditions

• Acute Ischemic Stroke

Interventions

Type	Name	Description
DRUG	Dexmedetomidine prolonged sedation	Dexmedetomidine for 24h after patients finished endovascular thrombectomy and returned to ICU.
DRUG	0.9% saline	An equal dose of 0.9% saline 24h after patients finished endovascular thrombectomy and returned to ICU.

Timeline

• Start date: 2024-03-01
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2021-06-07
• Last updated: 2023-12-20

Locations

1 site across 1 country: China