NCT04914039

Evaluation of CTA on the Assessment of Brain Death

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 63 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 12 Years – 72 Years
• Healthy volunteers: Not accepted

Summary

At present, different countries have different standards for the diagnosis of brain death, but according to the classic brain death confirmation test, it needs to be combined with transcranial Doppler, EEG, evoked potential and apnea test in clinical practice. Some patients cannot undergo a complete clinical examination and apnea test due to certain factors, and the determination of brain death is limited. The American Academy of Neurology (AAN) guidelines regard cerebral angiography as an acceptable auxiliary examination and is widely regarded as the gold standard for cerebral blood flow evaluation. CT cerebrovascular angiography (CTA) is a noninvasive and widely used examination method that can identify missing or severely reduced cerebral blood flow. However, due to limited experience and lack of sufficient evidence to prove its reliability, it is not included in the AAN A recognized auxiliary examination; there are also a large number of domestic and foreign literature reports that CTA can be used as a new confirmation test for clinical judgment of brain death. This study aims to explore the value of CTA in the judgment of patients with brain death.

Conditions

• Brain Death

Interventions

Type	Name	Description
COMBINATION_PRODUCT	Combination Product	Cases of brain death confirmed by the classic brain death confirmation test
OTHER	NO CTA examination	NO CTA examination

Timeline

• Start date: 2021-02-01
• Primary completion: 2022-02-01
• Completion: 2023-02-01
• First posted: 2021-06-04
• Last updated: 2021-06-04

Locations

1 site across 1 country: China

Regulatory

• FDA-regulated drug study