NCT04912752

Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression

Copy Number Variation in Migraine and Gene Expression

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: University of Gaziantep · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Migraine is a common and possible hereditary disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.The CHRNA7 gene has a major role in the neuropsychiatric phenotypes observed in patients. The 15q13.3 gain/loss variation in this gene may be associated with migraine.

Detailed description

Migraine is a common neurological disorder. Although they have different genetic bases according to their types, cholinergic receptors after calcium channels play an important role in the clinic and genetics of the disease. Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene.

Conditions

• Migraine

Interventions

Type	Name	Description
GENETIC	Migraine CNV	Copy number variation effect on migraine disease

Timeline

• Start date: 2020-04-05
• Primary completion: 2020-12-10
• Completion: 2021-01-02
• First posted: 2021-06-03
• Last updated: 2021-06-03

Locations

1 site across 1 country: Turkey (Türkiye)