NCT04912622

RPE Characterisation With Transscleral Optical Phase Imaging in Retinal Disorders

Cross Sectional Study: in Vivo Morphometric Characterisation of Human Retinal Pigment Epithelium With Transscleral Optical Phase Imaging in Photoreceptor/ Retinal Pigment Epithelium/ Bruch's Membrane/ Choriocapillaris Complex Disorders

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 210 (actual)
• Sponsor: Luzerner Kantonsspital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Accumulating evidence suggest that the functional unit of photoreceptor/ retinal pigment epithelium (RPE)/Bruch's membrane/choriocapillaris plays a key role in pathophysiologic processes of a wide range of medical retinal disorders of the eye. Little is known about in vivo morphometric characteristics of human RPE cells as in vivo observation of these cells was so far technically challenging and hence nearly impossible to implement in a clinical setting. Transscleral optical phase imaging is a novel in-vivo microscopy technique allowing human RPE imaging on a cellular level with the potential of clinical application in a multimodal retinal imaging approach for diagnostic purpose in medical retina patients.

Conditions

• Retinal Disease
• Eye Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Clinical Trial	Retinal image acquisition with Cellularis version 2.0

Timeline

• Start date: 2021-05-19
• Primary completion: 2022-10-31
• Completion: 2022-10-31
• First posted: 2021-06-03
• Last updated: 2023-03-07

Locations

1 site across 1 country: Switzerland