NCT04902339

Near-infrared Spectroscopy-based Neurofeedback as Adjunct to Mindfulness-Oriented Recovery Enhancement in Persons With Chronic Pain

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 142 (actual)
• Sponsor: University of Utah · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary aim of this pilot trial is to enhance the efficacy of the Mindfulness-Oriented Recovery Enhancement (MORE) intervention by adding neurofeedback (NF) of the Orbitofrontal Cortex (OFC) as an adjunct to the savoring component of MORE. We hypothesize that the use of NF to train OFC responses during savoring will amplify patients' ability to savor and thereby increase brain responsivity to natural rewards; such enhanced reward responding will in turn be associated with improvements in clinical outcomes (e.g., pain, analgesic use).

Conditions

• Chronic Pain Syndrome
• Opioid Use

Interventions

Type	Name	Description
BEHAVIORAL	Mindfulness-Oriented Recovery Enhancement	8 weeks of therapy integrating mindfulness, reappraisal, and savoring skills.
OTHER	Neurofeedback	Near-infrared spectroscopy neurofeedback during savoring practice.
BEHAVIORAL	Supportive Psychotherapy	8 weeks of supportive, process-oriented psychotherapy.

Timeline

• Start date: 2021-04-03
• Primary completion: 2025-04-03
• Completion: 2025-04-03
• First posted: 2021-05-26
• Last updated: 2025-04-22

Locations

1 site across 1 country: United States