NCT04897919

Effectiveness and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for Treating Malaria

Effectiveness and Safety of Artemether + Lumefantrine and Dihydroartemisinin + Piperaquine for the Treatment of Uncomplicated Malaria in Guinea-Bissau

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 474 (actual)
• Sponsor: Bandim Health Project · Academic / Other
• Sex: All
• Age: 6 Months
• Healthy volunteers: Not accepted

Summary

Objective: to measure the effectiveness and safety of (artemether-lumefantrine) AL and (dihydroartemisinin-piperaquine) DP in patients (\> 6 months) suffering from uncomplicated P. falciparum malaria. Patients coming to Bandim Health Center will, if accepting, be randomised to study-arm. Medication will be provided and first dose given. Patients will be followed-up on day 7, 14, 28, and 42 with clinical evaluation, malaria film and filter-paper blood-sample for polumerase chain reaction (PCR) on re-appearing parasites. On day 21 and 35 a telephone-interview will be performed. Primary out-come: adequate clinical and parasitological response rate on day 42. Secondary out-comes: safety, re-infection vs recrudescence, and haemoglobin on day 42.

Detailed description

To objective of the study: 1. To measure the efficacy and safety of AL and DP in children for treating uncomplicated P. falciparum malaria. 2. To determine the capacity of each drug combination to protect against re-infection. 3. To differentiate recrudescence from re-infections using PCR based methods 4. To determine haemoglobin values on days 0 and 42 5. To determine genetic polymorphisms in P. falciparum causing reparasitaemia. Study design This will be an open label, randomized, non inferiority trial conducted at the Bandim Health Centre, Guinea-Bissau. Patients with uncomplicated malaria who meet study inclusion criteria will be enrolled, randomised to treatment with either AL or DP. Medication will be provided and first dose given at the health centre. Efficacy and safety evaluation Treatment outcomes will be early treatment failure, late clinical failure, late parasitological failure or adequate clinical and parasitological response as defined by the WHO. All will be asked routinely about previous symptoms and about symptoms that have emerged since the previous follow up visit. All adverse events will be recorded in the case record forms. 100µL of blood will be collected on Whatman 3MM filter-paper using a capillary tube on day 0, 7, 14, 28,and 42 and whenever re-parasitaemia is detected. Filter-papers will be dried and then placed inside separate sealed plastic bags. In order to differentiate recrudescence from a re-infection genotyping using sequential analysis of pf-glurp, pfmsp1 and pfmsp2 will be done. Drug concentrations will be assessed on the week prior to re-parasitaemia. Haemoglobin concentration will be determined on day 0, 3 and 42 using a haemocueTM.

Conditions

• Malaria
• Effectiveness

Interventions

Type	Name	Description
DRUG	Dihydroartemisinin-piperaquine 160 mg/20 mg Oral Tablet	Dihydroartemisinin-piperaquine is given as recommended by manufacturer and compared to the Artemether-lumefantrine group.
DRUG	Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet	Artemether-Lumefantrine is given as recommended by manufacturer

Timeline

• Start date: 2015-08-01
• Primary completion: 2017-10-01
• Completion: 2018-12-01
• First posted: 2021-05-24
• Last updated: 2022-04-12

Locations

1 site across 1 country: Guinea-Bissau