NCT04890951

Hysterectomy Versus Uterine Preservation for Pelvic Organ Prolapse Surgery

Prospective Multi-site Cohort Study Investigating Hysterectomy Versus Uterine Preservation for Pelvic Organ Prolapse Surgery: The HUPPS Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 321 (estimated)
• Sponsor: University of Calgary · Academic / Other
• Sex: Female
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

Pelvic organ prolapse (POP) is the descent of pelvic organs into the vagina resulting in bulge symptoms and occurs in approximately 50% of women. Almost 20% of women will elect surgical correction of this condition by age 85. Removal of the uterus (hysterectomy) with concomitant vaginal vault suspension is a longstanding practice in POP surgery to address apical (uterine) prolapse. Yet, contemporary evidence on the merits of this approach relative to preservation of the uterus through suspension is needed to better inform surgical decision-making by patients and their healthcare providers. The objective of this trial is to evaluate POP-specific health outcomes and service utilization of women electing uterine suspension compared to those electing hysterectomy and vaginal vault suspension for POP surgery up to 1-year post-surgery.

Conditions

• Pelvic Organ Prolapse

Interventions

Type	Name	Description
PROCEDURE	Hysteropexy	Uterine preservation through suspension
PROCEDURE	Hysterectomy and vaginal vault suspension	Uterine removal and sewing the vagina upwards

Timeline

• Start date: 2020-07-01
• Primary completion: 2023-12-01
• Completion: 2024-12-01
• First posted: 2021-05-18
• Last updated: 2021-06-03

Locations

1 site across 1 country: Canada