NCT04890275

Blood Flow Restricted Resistance Training in Peripheral Arterial Disease

Blood Flow Restricted Resistance Training in Peripheral Arterial Disease: a Randomised Controlled Trial Feasibility Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Sheffield Hallam University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A randomised controlled trial evaluating the feasibility and acceptability of a 12 week lower body blood flow restricted resistance exercise programme for people with peripheral arterial disease.

Detailed description

The primary aim of this study is to determine the feasibility of 12 weeks of lower body resistance exercise performed with blood flow restriction (BFR) in people with peripheral arterial disease. Resistance exercise with BFR involves placing inflatable cuffs proximal to the exercise limbs in order to manipulate blood flow and enhance the training response. Secondary aim of this study is to evaluate changes in ABPI, muscle size, strength and physical function at mid-and post- intervention.

Conditions

• Peripheral Arterial Disease

Interventions

Type	Name	Description
OTHER	Blood flow restricted resistance exercise (BFR)	Following a 5-minute low intensity warm-up, the BFR cuff will be placed at the most proximal portion of the leg inflated to 50% limb occlusion following standard BFR guidelines. Participants will then perform leg press including 1 set of 30 reps, then 3 sets of 15 reps at 20% 1RM. Rest for 5 minutes without cuff inflation. Cuffs will be re inflated and participants will perform knee extension including 3 x 15 repetitions at 20% 1RM.
OTHER	Resistance exercise without blood flow restricted (NON-BFR)	Participants will follow the same exercise protocol as the blood flow restriction group but with out BFR.

Timeline

• Start date: 2021-04-21
• Primary completion: 2022-03-05
• Completion: 2022-04-30
• First posted: 2021-05-18
• Last updated: 2022-11-08

Locations

1 site across 1 country: United Kingdom