Clinical Trials Directory

Trials / Terminated

TerminatedNCT04876378

Impact of Breast Cancer Treatment on Joint Health, Cartilage Composition, and Bone Structure in the Knee and Hand

Status
Terminated
Phase
—
Study type
Observational
Enrollment
8 (actual)
Sponsor
University of California, San Francisco · Academic / Other
Sex
All
Age
70 Years
Healthy volunteers
Accepted

Summary

This study investigates the impact of breast cancer treatment on joint health, cartilage, composition, and bone structure in the knee and hand in patients with hormone-receptor positive stage I-III breast cancer and healthy patients. The investigators will use Magnetic Resonance Imaging (MRI) to assess the quality of hand and knee joints. This study may help doctors learn more about hand and knee joint pain that occurs during aromatase inhibitor treatment.

Detailed description

PRIMARY OBJECTIVE: I. To investigate pathological alterations in cartilage and joints in breast cancer patients on aromatase inhibitor (AI)s with and without pain and in healthy control patients. OUTLINE: Patients complete a series of questionnaires over 15 minutes about knee function and pain, as well as physical activity. Patients also undergo an MRI of about 60 minutes. After completion of study, a subset of patients are followed up at 6 months.

Conditions

Interventions

TypeNameDescription
PROCEDUREMagnetic Resonance ImagingUndergo MRI
OTHERQuestionnaire AdministrationComplete questionnaires

Timeline

Start date
2020-05-18
Primary completion
2022-05-24
Completion
2022-05-24
First posted
2021-05-06
Last updated
2022-09-09

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT04876378. Inclusion in this directory is not an endorsement.