NCT04875364

Do Endotypes Predict Response and Sequelae in OSA Patients

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: University of California, San Diego · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate why some people have Obstructive Sleep Apnea (OSA) and how the underlying cause may relate to OSA manifestations (including sleepiness and high blood pressure) and response to different therapeutic approaches (ie CPAP, eszopiclone, and supplemental oxygen). Understanding why someone has OSA could affect how best to treat that individual, but may also have an impact on what problems the disease might cause.

Conditions

• Obstructive Sleep Apnea
• Sleep Apnea
• Sleep Apnea, Obstructive
• Sleep
• Sleep Disorder

Interventions

Type	Name	Description
DRUG	Eszopiclone	2mg of Eszopiclone just before going to sleep.
OTHER	Supplemental Oxygen	Constant oxygen flow at 4 Liters per minutes for the duration of time in bed via nasal cannula.
DEVICE	Continuous Positive Airway Pressure (CPAP)	A standard CPAP device will be provided using the settings as prescribed by the treating physician.

Timeline

• Start date: 2020-08-01
• Primary completion: 2027-01-01
• Completion: 2027-01-01
• First posted: 2021-05-06
• Last updated: 2024-10-02

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study