NCT04873466

The Effects of Enzyme-rich Malt Extract on Chronic Constipation

The Effects of Enzyme-rich Malt Extract on Symptoms of Chronic Constipation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: The Functional Gut Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Participants with constipation will take enzyme-rich malt extract for 4 weeks whilst completing a daily bowel habit diary before and during intervention.

Detailed description

This pilot study is an open label, pre-post interventional study to evaluate the use of ERME in the treatment of people with chronic constipation. This study involves eligible participants that have a diagnosis constipation according to the Knowles-Eccersley-Scott Score (KESS). Participants will receive intervention with a food supplement enzyme-rich malt extract (ERME) at a dose of 15ml twice daily with food. Before intervention commences, participants will complete baseline breath samples and a 7 day stool diary to assess stool frequency and consistency. Participants will then receive the ERME as instructed and continue to complete a bowel diary. Then at 4 weeks since starting the intervention, participants will provide another breath sample and complete another set of breath samples.

Conditions

• Constipation
• Quality of Life
• Methane Production

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Enzyme-rich malt extract	Enzyme-rich malt extract (ERME) is a by-product of the malting process in which the cereal grain barley is dried. The ingredients are 100% barley malt extract. It smells and tastes sweet, with a runny jam-like texture. Malt extract has been used as a food stuff in baking and cookery for many years, but ERME is extracted by means which retains more active enzymes, such as amylase.

Timeline

• Start date: 2021-03-01
• Primary completion: 2021-12-31
• Completion: 2022-03-01
• First posted: 2021-05-05
• Last updated: 2022-09-23

Locations

1 site across 1 country: United Kingdom