NCT04866563

A Study of Efficacy and Safety of AX-8 in Chronic Cough

A Phase 2 Study to Assess the Efficacy and Safety of AX-8 in Patients With Chronic Cough

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 108 (actual)
• Sponsor: Axalbion SA · Industry
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This is a randomized, double-blind, placebo-controlled, crossover, multicenter study of AX-8 in participants with unexplained or refractory chronic cough designed to evaluate the effectiveness of AX-8 in reducing cough frequency.

Conditions

• Chronic Cough

Interventions

Type	Name	Description
DRUG	AX-8, Part 1 of the study	orally disintegrating tablets, BID
DRUG	Placebo, Part 1 of the study	orally disintegrating tablets, BID
DRUG	AX-8, Part 2 of the study	orally disintegrating tablets, TID
DRUG	Placebo, Part 2 of the study	orally disintegrating tablets, TID

Timeline

• Start date: 2021-08-11
• Primary completion: 2025-06-16
• Completion: 2025-06-16
• First posted: 2021-04-30
• Last updated: 2025-09-08

Locations

16 sites across 1 country: United Kingdom