NCT04862507

Improving Low ASPECTS Stroke Thrombectomy

Improving Low Alberta Stroke Program Early ct Score Stroke Thrombectomy

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Universitätsklinikum Hamburg-Eppendorf · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Improving Low ASPECTS Stroke Thromectomy (I-LAST) is an academic, independent, prospective, multicenter, observational registry study. Consecutive patients treated with endovascular stroke treatment will be enrolled in German stroke centers. Patients receive regular care and data will be collected as part of clinical routine. Baseline clinical and procedural information as well clinical follow-up information during in-hospital stay, and up to 90 days of stroke onset are collected. Data collected include demographics, National Institute of Health Stroke Scale (NIHSS) on admission, pre-treatment ASPECTS, information on timing and success of interventional treatment, procedural complications, intracranial hemorrhage, and functional outcome. Advanced imaging biomarkers will be tested and validated aiming to improve treatment selection and outcome prediction of patients presenting with extensive baseline infarction.

Detailed description

This study aims to investigate the role of advanced imaging biomarkers in patients with large early infarct, in particular quantitative lesion water uptake (Minnerup et al. Annals of Neurology 2016), arterial and venous collateral circulation (Faizy et al. Radiology 2021), and multivariate CTP-derived parameters (Kemmling et al. JCBFM 2015). The goal is to use these imaging biomarkers as specific selection criterion to predict clinical benefit after reperfusion despite extensive baseline infarct lesions, also as a method of monitoring adjuvant neuroprotective agents after reperfusion therapy (for instance anti-edematous medication).

Conditions

• Acute Ischemic Stroke

Interventions

Type	Name	Description
OTHER	Telephone call on day 90	telephone call on day 90 to assess the primary outcome (mRs 90)
DIAGNOSTIC_TEST	Quantification of lesion water uptake by CT densitometry	Retrospective quantification of lesion water uptake by CT densitometry in admission and follow-up imaging

Timeline

• Start date: 2023-05-01
• Primary completion: 2027-01-01
• Completion: 2028-01-01
• First posted: 2021-04-28
• Last updated: 2023-05-24

Locations

8 sites across 2 countries: Germany, Switzerland