NCT04823741

Molecular, Pathologic Intra Tumoral Heterogeneity in Malignant Pleural Mesothelioma

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years – 95 Years
• Healthy volunteers: Not accepted

Summary

Malignant pleural mesothelioma (MPM) is a rare pleural cancer, which could be primary or secondary to an asbestos exposure. To enhance our knowledge of this rare disease, an exploration of genetic and tumor mechanism is mandatory. One of the principal difficulty is to harvest sufficient tumour pieces to perform multi-omics analysis. The goal of the SCITH-MESO study is to harvest larges pieces of tumour during a routine surgical procedure of MPM diagnosis by mean of pleural biopsies during VATS surgery. Operating samples will increase a tissue bank collection (CRB).

Conditions

• Mesothelioma, Malignant
• Gene Abnormality
• Pleural Mesothelioma

Interventions

Type	Name	Description
GENETIC	PLEURAL BIOCOLLECTION OF MALIGNANT PLEURAL MESOTHELIOMA	All patient with suspected malignant pleural mesothelioma requiring surgical biopsy after validation in oncologic multidisciplinary board will be included. During a standardized routine procedure of pleural biopsy by mean of general anesthesia and video thoracoscopic approach, 3 - 5 biopsies are realized. During this procedure, blood samples are collected and a piece of biopsy will be used for the constitution of a specific bio collection in the CRB (centre de ressources biologiques).

Timeline

• Start date: 2022-02-11
• Primary completion: 2026-02-11
• Completion: 2026-02-11
• First posted: 2021-04-01
• Last updated: 2024-02-01

Locations

1 site across 1 country: France