NCT04810858

Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 220 (estimated)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 25 Years – 59 Years
• Healthy volunteers: Accepted

Summary

This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.

Conditions

• Cannabis
• HIV
• Inflammation
• Cognition
• Neuroimaging

Interventions

Type	Name	Description
OTHER	Multimodal, multi-parametric MRI	The investigators will use multimodal, multi-parametric sequences to investigate neuroinflammatory and neurodegenerative processes in vivo. Participants will be assessed three times over 2 years.
OTHER	Immune and cytokine profiling	Blood samples will be collected for immune and cytokine profiling. Participants will be assessed three times over 2 years.
BEHAVIORAL	Neuropsychological testing	Participants will have neuropsychological testing three times over 2 years.

Timeline

• Start date: 2021-08-18
• Primary completion: 2027-05-31
• Completion: 2027-05-31
• First posted: 2021-03-23
• Last updated: 2026-03-31

Locations

1 site across 1 country: United States