NCT04804345

AProtinin Versus Tranexamic Acid in Cardiac Surgery Patients With High-risk for Excessive Bleeding

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 693 (actual)
• Sponsor: University Hospital, Bordeaux · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In this before-after multicenter study the authors tested the hypothesis that the prophylactic use of aprotinin compared to tranexamic acid could reduce the proportion of patients presenting severe perioperative bleeding.

Detailed description

Perioperative bleeding remains a real challenge for physicians managing cardiac surgical patients. In patients at high risk for excessive bleeding the prophylactic use of antifibrinolytics may be useful. This study propose to compare the efficacity and innocuity of aprotinin and tranexamic acid to reduce the proportion of patient presenting severe peri-operative bleeding according the Universal Definition of Perioperative Bleeding (UDPB) classification.

Conditions

• Cardiac Surgery
• Cardiopulmonary Bypass
• High Risk Bleeding

Interventions

Type	Name	Description
OTHER	standard of care	retrospective study: standard of care

Timeline

• Start date: 2021-03-31
• Primary completion: 2021-08-31
• Completion: 2021-08-31
• First posted: 2021-03-18
• Last updated: 2022-03-03

Locations

7 sites across 1 country: France