NCT04798664

Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 3,228 (actual)
• Sponsor: Abramson Cancer Center at Penn Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To compare the effectiveness of four interventions to promote sustained, biochemically confirmed smoking abstinence for 6 months among underserved smokers referred for lung cancer screening at four large U.S. health systems.

Detailed description

We will conduct a 4-arm randomized trial comparing 4 interventions to promote sustained, biochemically confirmed smoking abstinence for 6 months among smokers in underserved demographic groups. The 3,200 participants to be enrolled will be current smokers who are Black, Hispanic, and/or have low socioeconomic status (defined as household income \<200% of the federal poverty line or a high school education or less) or rural residence who are referred for low-dose computed tomography (LDCT) screening at 4 large health systems. All adult patients with LDCT orders will be further screened for eligibility. Eligible patients will enroll with opt-out consent and complete the study using the NIH-funded Way to Health online research portal. The primary outcome will be biochemically confirmed, sustained abstinence from smoking tobacco for 6 months following participants' selected quit dates. Relapse rates will be tracked at 12 months.

Conditions

• Smoking Cessation

Interventions

Type	Name	Description
BEHAVIORAL	Removal of Financial Barriers	Free access to nicotine replacement therapies and/or reimbursement for smoking cessation prescription medications
BEHAVIORAL	Financial Incentives	Financial incentive plan of up to $600 for biochemically-confirmed, sustained abstinence for 6 months.
BEHAVIORAL	Mobile Health Application	Episodic future thinking tool to overcome temporal discounting of future

Timeline

• Start date: 2021-05-17
• Primary completion: 2024-11-04
• Completion: 2025-04-29
• First posted: 2021-03-15
• Last updated: 2026-02-25
• Results posted: 2026-02-25

Locations

5 sites across 1 country: United States