NCT04788680

Effects of Non-calorie Sweeteners, Mono- and Disaccharides on Intestinal Barrier Function

Assessment of the Effects of Non-calorie Sweeteners on Gut Barrier and Inflammatory Markers Compared to Those of Sugars in Healthy Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.

Detailed description

In the intervention study normal weight participants will receive beverages sweetened with non-nutritive sweeteners, mono- and disaccharides for a defined number of days. Before and after intervention parameters of intestinal barrier function will be assessed.

Conditions

• Dietary Habits
• Endotoxemia

Interventions

Type	Name	Description
OTHER	Dietary intervention 1	Participants receive a beverage with a defined amount of non-nutritive sweetener.
OTHER	Dietary Intervention 2	Participants receive a beverage with a defined amount of non-nutritive sweetener and maltodextrin.
OTHER	Dietary Intervention 3	Participants receive a beverage with a defined amount of monosaccharide.
OTHER	Dietary Intervention 4	Participants receive a beverage with a defined amount of disaccharide.

Timeline

• Start date: 2021-03-01
• Primary completion: 2022-12-31
• Completion: 2022-12-31
• First posted: 2021-03-09
• Last updated: 2023-11-01

Locations

1 site across 1 country: Austria