NCT04772651

Mediterranean Diet and the Microbiota Gut Brain Axis in Major Depression

Mediterranean Diet and the Microbiota Gut Brain Axis- Does Diet Interact With the Function of Vagal Nerve in Major Depression?

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 108 (estimated)
• Sponsor: Medical University of Graz · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess the efficacy of a Mediterranean diet on the function of the vagal nerve in patients with depression.

Detailed description

After being informed about the study and potential risks, all patients giving written informed consent will be screened for eligibility. Subjects meeting the inclusion criteria will be randomized in a group recieiving a Mediterranean diet (3 mediterranean meals a day) and dietary coaching (1 session per week for 4 weeks) or a group with conventional hospital food and psychoeducation on depression (1 session per week for 4 weeks).

Conditions

• Depression

Interventions

Type	Name	Description
OTHER	Mediterranean Diet	Diet meeting the requirements for mediterranean style (rich in vegetables, fruit, olive oil, fish) (Davis et al., 2015)
OTHER	Normal hospital diet	Normal hospital diet
OTHER	dietary coaching	dietary coaching
OTHER	Psychoeducation on depression	Psychoeducation on depression (50minutes once a week for 4 weeks)

Timeline

• Start date: 2025-11-01
• Primary completion: 2028-09-01
• Completion: 2029-09-30
• First posted: 2021-02-26
• Last updated: 2023-03-14