NCT04765137

Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)

Targeting Cerebrovascular Reactivity for Precision Medicine: Pilot Trial of Atorvastatin

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 60 Years – 95 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.

Detailed description

Participants are first being informed about potential benefits and risks of the study and are required to give written consent. After that participants will undergo detailed phone screen to determine eligibility for study entry. At week 0, participants who meet eligibility requirements will be prescribed atorvastatin (40 mg, once in the evening) in an open-label manner.

Conditions

• Mild Cognitive Impairment

Interventions

Type	Name	Description
DRUG	Atorvastatin Oral Tablet	Atorvastatin pill 40 mg to be taken every night

Timeline

• Start date: 2021-05-21
• Primary completion: 2026-07-31
• Completion: 2026-12-31
• First posted: 2021-02-21
• Last updated: 2025-08-06

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study