Trials / Terminated
TerminatedNCT04759872
Insulin and Muscle Fat Metabolism
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 9 (actual)
- Sponsor
- Oregon State University · Academic / Other
- Sex
- All
- Age
- 30 Years – 55 Years
- Healthy volunteers
- Accepted
Summary
Our objective in this study is to identify the extent to which insulin drives the accumulation of lipids in skeletal muscle of humans. We will test the hypothesis that 4-hours of mild hyperinsulinemia will result in significant muscle lipid accumulation and that such effects will be similar in lean and overweight/obese humans.
Conditions
- Overweight and Obesity
- Insulin Resistance
- Metabolic Disease
- Mitochondrial Metabolism
- Sedentary Lifestyle
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Hyperinsulinemic-euglycemic Clamp | Participants will be administered a constant-rate insulin infusion (to induce mild hyperinsulinemia), with an infusion of dextrose to maintain blood glucose concentration (to maintain euglycemia). |
Timeline
- Start date
- 2021-02-22
- Primary completion
- 2022-06-07
- Completion
- 2022-06-07
- First posted
- 2021-02-18
- Last updated
- 2022-06-10
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT04759872. Inclusion in this directory is not an endorsement.