Trials / Active Not Recruiting
Active Not RecruitingNCT04743466
Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes
Evaluation of a Causal Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes: A Mendelian Randomization Analysis
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 1 (actual)
- Sponsor
- M.D. Anderson Cancer Center · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Accepted
Summary
This study evaluates the association between testosterone levels and risk of dementia and adverse mental health outcomes (e.g. depression and anxiety). It is not known whether low testosterone levels may be associated with an increased risk of dementia. Learning about the association between testosterone levels and risk of dementia may help determine the long-term effects of androgen deprivation therapy and may help improve quality of life.
Detailed description
PRIMARY OBJECTIVE: I. To use a Mendelian randomization study design to determine whether genetically predicted decreased testosterone levels are associated with an increased risk of dementia. SECONDARY OBJECTIVE: I. To examine whether genetically predicted decreased testosterone levels are associated with worse cognitive function and adverse mental health outcomes. OUTLINE: Patients' records from institutional or national biobanks are reviewed.
Conditions
- Anxiety Disorder
- Depression
- Genetic Disorder
- Hematopoietic and Lymphoid Cell Neoplasm
- Malignant Solid Neoplasm
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Electronic Health Record Review | Biobank records are reviewed |
Timeline
- Start date
- 2020-02-13
- Primary completion
- 2028-11-30
- Completion
- 2028-11-30
- First posted
- 2021-02-08
- Last updated
- 2026-02-19
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT04743466. Inclusion in this directory is not an endorsement.