NCT04717947

Interval Between Neoadjuvant Therapy and Surgery in the Treatment of Locally Advanced Rectal Cancer (CRONOS)

Interval Between Neoadjuvant Therapy and Surgery in the Treatment of Locally Advanced Rectal Cancer

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 911 (actual)
• Sponsor: Hospital Clinic of Barcelona · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The investigators evaluate the response of rectal cancer to neoadjuvant therapy and classify the response according to specific periods of time after the end of neoadjuvant treatment.

Detailed description

In the treatment of locally advanced rectal cancer, an optimal interval between neoadjuvant therapy and surgery might improve oncological outcomes. Besides, those patients who achieve a good response might benefit from active surveillance, avoiding surgical comorbidities. This optimal interval is yet to be defined. This study will aim to better define the role of time interval between the end of neoadjuvant therapy (NAT) and TME in Spanish regions, together with analyzing the importance of restaging MRI and define the basis for implementing a "watch and wait" protocol.

Conditions

• Rectal Cancer
• Neoadjuvant Therapy

Interventions

Type	Name	Description
PROCEDURE	Interval between NAT and surgery	Evaluate three groups according to the interval between the end of neoadjuvant therapy and surgery.

Timeline

• Start date: 2020-02-25
• Primary completion: 2020-02-25
• Completion: 2021-06-25
• First posted: 2021-01-22
• Last updated: 2021-02-04

Locations

1 site across 1 country: Spain