NCT04711564

The Effects of Different Lipid Emulsions on the Adipokines in Critically Ill Patients With Sepsis

The Effects of Different Lipid Emulsions on the Adipokines, Inflammatory Markers and Mortality in Critically Ill Patients With Sepsis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Karadeniz Technical University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Intravenous lipid emulsions contain a number of biologically active ingredients, but the most important are fatty acids. Different fatty acids can affect a number of different physiological processes in different ways in critically ill patients. Adipose tissue can play an important role in metabolic changes of critical illnesses and in adaptation to stress through structural as well as functional changes Although it is known that serum adipokine and cytokine response changes in critical sepsis patients, the factors affecting these changes and the metabolic consequences of these changes are not well defined. The aim of this study was to evaluate the effects of intravenous lipid emulsions on serum adipokine and cytokine levels in patients with sepsis. Secondly, this is to determine the adipokine and cytokine kinetics in the sepsis process and their relationship with mortality in patients with sepsis.

Conditions

• Sepsis

Interventions

Type	Name	Description
OTHER	Olive oil-based intravenous fat emulsions	Parenteral nutrition planned according to the requirements of the patients is given for ten days.
OTHER	Soybean-based intravenous fat emulsions	Parenteral nutrition planned according to the requirements of the patients is given for ten days.

Timeline

• Start date: 2018-03-29
• Primary completion: 2020-03-25
• Completion: 2020-04-15
• First posted: 2021-01-15
• Last updated: 2021-01-15

Locations

1 site across 1 country: Turkey (Türkiye)